The disclosure provides compositions, methods of manufacture and methods of use of antibodies and fragments that bind Staphylococcus aureus alpha toxin. More specifically, the disclosure provides VH CDR and VL CDR region sequences of antibodies or antigen-binding fragments. Method of preventing, treating or managing a condition associated with Staphylococcus aureus infection using the antibodies are also disclosed.La présente invention concerne des compositions, des procédés de fabrication et des procédés d'utilisation d'anticorps anti-alpha toxine et des fragments de ceux-ci.