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IN VITRO METHOD FOR SCREENING FOR CANDIDATE COMPOUNDS FOR PREVENTING AND/OR ATTENUATING AGEING OF THE SKIN, AND/OR FOR HYDRATING THE SKIN
专利权人:
发明人:
Elena FEDOROVA,Christelle LASSERRE
申请号:
US15196393
公开号:
US20160304955A1
申请日:
2016.06.29
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The identification and the use of compounds which activate the expression of at least one gene selected from LARGE, HS6ST2 and ST8SIA1, for preventing and/or attenuating ageing, and/or for hydrating skin is provided. An in vitro method for screening for candidate compounds for preventing and/or attenuating ageing of the skin, and/or for hydrating the skin, includes the following steps:(a) bringing at least one test compound in contact with a sample of keratinocytes(b) measuring the expression of at least one gene selected from LARGE, HS6ST2 and ST8SIA1, in said keratinocytes(c) selecting the compounds for which an activation of at least 1.4 fold of the expression of at least one of said genes is measured in the keratinocytes treated in (a) compared with the untreated keratinocytes.
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