NO ZAESUNG,НО Заесунг,KIM DZAESEUNG,КИМ Дзаесеунг,BRODEN PRISIJ,БРОДЕН Присий,SEO MIN DZUNG,СЕО Мин Дзунг,KIM JOUNG MI,КИМ Йоунг Ми,CHEKETTO DZHONATAN,ЧЕКЕТТО Джонатан,DZEON KHEEKIOUNG,ДЗЕОН Хеекиоунг
申请号：
RU2012144317
公开号：
RU2576662C2
申请日:
2011.03.18
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to heterocyclic compounds of formula Ib and its pharmaceutically acceptable salts, wherein X, Y and Z represent CH o is equal to 1 n is equal to 0 m is equal to 1 or 2 A represents C=O W represents NH in each specific case, Ris independently specified in a group consisting of C-Calkyl in each specific case, Ris independently specified in a group consisting of halogen, C-Calkyl optionally substituted by halogen OR, -NO, heteroaryl representing pyridyl in each specific case, Ris independently specified in a group consisting of C-Calkyl and C-Chalogenalkyl Rrepresents a fragment specified in a group consisting ofwherein m is equal to 0, 1, 2, 3 or 4 in each specific case, Ris independently specified in a group consisting of hydrogen and C-Calkyl in each specific case, Ris independently specified in a group consisting of hydrogen, C-Calkyl optionally substituted by ORgroup, heterocyclyl representing morpholinyl, or by hydroxyl C-Ccycloalkyl, C-Chalogenalkyl, hydroxyl, -OR, C(O)R, -C(O)N(R), phenyl optionally substituted by halogen, -N(R)C(O)Rgroup or ORgroup benzyl optionally substituted by halogen or ORgroup in each specific case, Ris independently specified in a group consisting of hydrogen, C-Calkyl phenyl optionally substituted by halogen, C-Chalogenalkyl or ORgroup, benzyl optionally substituted by halogen in each specific case, Ris independently specified in a group consisting of hydrogen, C-Calkyl, C-Chalogenalkyl, C-Ccycloalkyl, phenyl substituted by halogen or ORgroup. The invention also refers to specific compounds, using the above compounds, a pharmaceutical composition based on the compound of formulaEFFECT: activity of certain known compounds has been examined, and the new compounds possessing inhibitory activity on mycobacterial growth have been produced.10 cl, 3 dwg, 2 tbl, 3 exИзобретение относится к гетероциклическим соединениям формулы Ib и к его фармацевтически приемлемым солям, где X, Y и Z п
