Southern Research Institute;Sanford-Burnham Medical Research Institute
发明人:
HEIL, Marintha L.,COSFORD, Nicholas D.P.,ARDECKY, Robert,ZOU, Jiwen
申请号：
ES12824120
公开号：
ES2616342T3
申请日:
2012.08.10
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of Formula (1) or a pharmaceutically acceptable salt thereof: wherein each of X1 and X2 independently is halo or OSO2Ra, wherein Ra is alkyl, alkenyl or alkynyl； Q is cycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl or heteroaryl, each of which is independently optionally substituted with alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl, heteroaryl, halo, nitro, oxo, -CH>； = NH, cyano, alkyl-Rb, CH>； = NORb, ORb, OC (O) Rb, OC (O) ORb, OC (O) SRb, SRb, C (O) Rb, C (O) ORb, C (O ) SRb, C (O) NRcRd, SORb, SO2Rb, NRcRd, alkyl-NRcRd or N (Rc) C (O) Rd, in which each of Rb, Rc and Rd, independently, is H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, halo, cyano, nitro, amino, hydroxyl, alkylamino, haloalkyl or alkoxy； Z is eliminated or is (CH2) m in which m is an integer from 1 to 10； and each of R1 and R2 independently is H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl, heteroaryl, halo, nitro, oxo, -CH>； = NH, cyano, alkyl-Rb, CH>； = NORb, ORb, OC (O) Rb, OC (O) ORb, OC (O) SRb, SRb, C (O) Rb, C (O) ORb, C (O) SRb, C (O) NRcRd, SORb, SO2Rb, NRcRd, alkyl-NRcRd or N (Rc) C (O) Rd, in which: cycloalkyl refers to a saturated hydrocarbon ring system having 3 to 30 carbon atoms； Cycloalkenyl refers to a non-aromatic hydrocarbon ring system having 3 to 30 carbons and one or more double bonds； "heterocycloalkyl" refers to a 5-8 membered monocyclic, 8-12 membered bicyclic or 11-14 membered tricyclic non-aromatic ring system having one or more heteroatoms； "heterocycloalkenyl" refers to a 5-8 membered monocyclic, 8-12 membered bicyclic or 11-14 membered tricyclic non-aromatic ring system having one or more heteroatoms and one or more double bonds； aryl refers to a 6-carbon monocyclic, 10-carbon bicyclic, 14-carbon tricyclic aromatic ring system； "heteroaryl" refers to a 5-8 membered monocyclic, 8-12 membered bicyclic or 11-14 membered tr
