MULTILAYER GENETIC SAFETY KILL CIRCUITS BASED ON SINGLE CAS9 PROTEIN AND MULTIPLE ENGINEERED GRNA IN MAMMALIAN CELLS

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专利权人:

发明人:

Samira Kiani,Ron Weiss,Mohammad Reza Ebrahimkhani

申请号：

US15755623

公开号：

US20180251789A1

申请日:

2016.09.01

申请国别(地区):

US

年份:

2018

代理人:

摘要：

Aspects of the disclosure relate to synthetic regulatory systems composed of a multifunctional clustered regularly interspaced short palindromic repeat (CRISPR)-associated (Cas) nuclease and at least two distinct guide RNAs (gRNAs). The synthetic regulatory system modulates cleavage and transcription, including repression and activation, in a mammalian cell such as a human cell.

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