Jeffrey Jacob;Jason A. Zell;Christine E. Mclaren;Frank L. Meyskens, JR.;Kavitha P. Raj;Eugene W. Gerner
发明人:
Kavitha P. Raj,Jason A. Zell,Christine E. Mclaren,Eugene W. Gerner,Frank L. Meyskens, JR.,Jeffrey Jacob
申请号：
US13697984
公开号：
US20130217743A1
申请日:
2011.05.13
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Controlling exogenous polyamines may be used, in some aspects, as an adjunctive strategy to chemoprevention with polyamine inhibitory agents, for example, anti-carcinoma combination therapies comprising ornithine decarboxylase (ODC) inhibitor and a spermidine/spermine N1-acetyltransferase expression agonist, optionally based on a patient's ODC1 promoter genotype. Assessing a tissue polyamine level or tissue polyamine flux may be used in some aspects, for predicting the efficacy of an anti-carcinoma combination therapy comprising, for example, an ornithine decarboxylase (ODC) inhibitor and an agent that modulates the polyamine pathway to reduce overall cellular polyamine content.
