DIZIO, James P.,TIAN, Zhicheng,BJORK, Jason W.,DETERMAN, Amy S.,ASMUS, Robert A.,O'HARE, Jonathan J.
申请号：
EP17859060
公开号：
EP3522941A4
申请日:
2017.10.04
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
Provided is a method of forming a fibrinogen hydrogel composition, the method including providing a fibrinogen hydrogel or precursor thereof, comprising fibrinogen hydrogel forming salt. The fibrinogen hydrogel forming salt concentration is greater than or equal to the threshold concentration to form a fibrinogen hydrogel. The method further includes denaturing the fibrinogen hydrogel such as by heating. The method optionally further includes combining the fibrinogen hydrogel with a carrier material. When present, the concentration of the carrier material typically ranges from 0.1 to about 50 wt.-%. The method further includes reducing the salt concentration below the threshold concentration to form a fibrinogen hydrogel.
