VARIANT ACTRIIB PROTEINS AND USES THEREOF

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专利权人:

Acceleron Pharma Inc.

发明人:

Ravindra Kumar,Asya Grinberg,Erik M. Vogan

申请号：

US16340048

公开号：

US20200055919A1

申请日:

2017.10.05

申请国别(地区):

US

年份:

2020

代理人:

摘要：

In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of red blood cells or a tissue, such as bone, cartilage, muscle, fat, and/or neuronal tissue. The present invention also provides methods of screening compounds that modulate activity of an ActRIIB protein and/or an ActRIIB ligand. The compositions and methods provided herein are useful in treating diseases associated with abnormal activity of an ActRIIB protein and/or an ActRIIB ligand.

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