Claim 1: a compound having the structure of formula (1) or a pharmaceutically acceptable Salt thereof,Where: is a remainder formula (2)； l u00b9 and L u00b2 are selected independently from a link or [c] (Q； Q r u2076r u2076) each independently selected from - ch u2082 - or - C (= o) - W is selected from a link or； r u00b9 is selected from the group consisting of H, alq Uilo c u2081 u208b u2081 u2082, - C (o) - r u2075, ch u2082 - o-alkyl c u2081 u208b u2086, 2 - tetrahydro-2h-pyran,And the rest of formula (2)； R u00b2 is selected from the group consisting of H, alkyl c u2081 u208b u2081 u2082, c u2081 u208b u2086 or u2074 - alkyl -, alkyl - or c u2081 u208b u2086 c u2081 u208b u2086 alkyl, - C (o) - ( u02b3nr u2077r u2078 r u2075, ch u2082) and - (ch u2082) u02b3n u207a ( u2083, r u2074) where, when and R u00b2 r u00b9 W is, or can be taken opcionalment And along with the o and N are respectively with which United to form a Ring of heterociclilo 4 to 8 members,Where the heterociclilo Ring can be optionally substituted by one or two groups r u00b9 u00b9； r u00b3 is selected from the group consisting of hydrogen, alkyl c u2081 u208b u2081 u2082 nr u00b9r u00b2 or u2075, -, -, or a whole group of formula (3),Where: X is a monocyclic or bicyclic aryl c u2085 u208b u2081 u2084； and selected from a heterociclilo c u2082 u208b u2089 monocyclic or bicyclic heteroaryl c u2082 u208b u2089 or a monocyclic or bicyclic, each Bearing one to three heteroatoms selected from S,N or o, and Z is a monocyclic or bicyclic cycloalkyl c u2083 u208b u2088； R u00b2 and r u00b3 can be optionally together with nitrogen and with the L u00b2 respectively that are United to form a Ring of heterociclilo 4 to 8 members,Where the heterociclilo Ring can be optionally substituted by one or two groups r u00b9 u00b9； r u2074 is selected from the group consisting of H, alkyl c u2081 u208b u2086； r u2075 is selected from the group consisting of H, alkyl c u2081 u208b u2086 r u00b3 (-, -, and - u02b3nr
