#$%^&*AU2016259318A120161201.pdf#####ABSTRACT The present invention relates to a method of controlling the discomfort level experienced by a subject. The method comprises receiving a signal from the subject to initiate comfort relief, determining vital sign data of the subject, determining whether the vital sign data fulfils a predetermined criterion, and performing an infusion regime of infusing a comfort relief drug into the subject based on whether the vital sign data fulfils the predetermined criterion.WO 2012/128718 PCT/SG2012/000090 3/3 Vital sign data such as pulse Signal oximetry, received from heart rate, subject fetal heart rate F determined 152 150 Predetermined criterion fulfilled 154 Administration of comfort relief drug to subject performed 156 FIGURE 2