The Board of Trustees of the Leland Stanford Junior University
发明人:
James Chang,Colin Woon,Hung Pham
申请号：
US14363283
公开号：
US20140350677A1
申请日:
2012.12.07
申请国别(地区):
US
年份:
2014
代理人:
摘要：
One aspect of the present invention is a method of producing a decellularized composite tissue bioscaffold for musculoskeletal tissue interface reconstruction by physicochemically treating a musculoskeletal tissue interface isolated from allogeneic sources. In certain embodiments, such musculoskeletal tissue interfaces can also be isolated from xenogeneic sources. The method comprises treatment of the interface with detergents, chemical oxidants and ultrasonic energy, and wash steps in between to remove residual detergents as well as oxidants. The resulting bioscaffold may be freeze-dried or lyophilized, sterilized and aseptically packaged for subsequent use.
