Instrumentation and methods are provided for mounting a surgical navigation reference frame to a patient. A trocar may be positioned within a cannula to form an insertion device adapted for percutaneous introduction into the patient. A bone anchor having a bone engaging portion is inserted through the cannula for anchoring to bone. The bone anchor cooperates with the cannula to form a mounting device adapted for coupling with the surgical navigation reference frame. An image-guided surgical procedure may be performed at a location remote from the anchoring location. In a specific embodiment, a minimally invasive surgical procedure is performed, with a reference frame anchored to the pelvic bone, and more specifically to the iliac region of the pelvic bone. A second reference frame may be anchored to the femur.