The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-κB-inducing kinase (NIK - also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders.本發明涉及有用於在哺乳動物中進行治療和/或預防之藥物試劑,並且尤其涉及有用於治療疾病(如癌症、炎性病症、代謝障礙及自身免疫病症)的NF-κB誘導的激酶(NIK,也稱為MAP3K14)之抑制劑。本發明還針對包含這樣的化合物之藥物組成物;針對製備這樣的化合物和組成物之方法;並且針對這樣的化合物或藥物組成物用於預防或治療疾病(如癌症、炎性病症、包括肥胖症和糖尿病的代謝障礙以及自身免疫病症)之用途。
