Amod A. Sarnaik,Jeffrey S. Weber,Shari Pilon-Thomas,Laszlo G. Radvanyi,Jessica Ann Chacon,James J. Mule
申请号：
US15303201
公开号：
US20170044496A1
申请日:
2015.04.10
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Disclosed herein is a method for ex vivo expanding tumor-infiltrating lymphocytes for use in adoptive cell therapy (ACT). The method involves culturing tumor fragments from the subject in a culture medium containing IL-2 and a 41BB agonist in an amount effective to expand tumor-infiltrating lymphocytes with enriched tumor-reactivity and specificity. Also disclosed is a method for treating a tumor in a subject that involves treating the subject with nonmyeloablative lymphodepleting chemotherapy, and administering tumor-infiltrating lymphocytes expanded by the disclosed methods.
