Device for the resection of the femur (11) that comprises a resection body (12) provided with resection grooves (13) configured to receive a cutting surgical instrument to obtain at least two sections (15, 16) of the femur (11), wherein the resection body (12) consists of two separate elements, able to be selectively assembled to each other in a stable and releasable manner, of which a first element is a cutting template (21) provided with the resection grooves (13), and a second element is a measuring and reference member (22) provided with a plurality of measuring and reference holes (24) configured to determine an angular offsetting with respect to the longitudinal axis (F) of the femur (11) and an axial translation along the longitudinal axis (F) of the femur (11) between the two sections (15, 16); releasable holding means (23) are provided between the cutting template (21) and the measuring and reference member (22); moreover the measuring and reference holes (24) are made on the measuring and reference member (22) according to a matrix (M) associated with axial and angular coordinates in ordered rows and columns.