Dihidropiridinona and piperidinona aryl compounds as inhibitors of monoacilglicerol acyltransferase (mgat2)； Composition and Pharmaceutical Combination； and use in the treatment and Prevention of diabetes, retinopathy, hyperglycemia, metabolic syndrome, and other diseases.
TURDI, HUJI,HANGELAND, JON J.,LAWRENCE, R. MICHAEL,CHENG, DONG,AHMAD, SALEEM,MENG, WEI,BRIGANCE, ROBERT PAUL,DEVASTHALE, PRATIK,ZHAO, GUOHUA
申请号：
CL2014001437
公开号：
CL2014001437A1
申请日:
2014.05.30
申请国别(地区):
CL
年份:
2014
代理人:
摘要：
The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are monoacylglycerol acyltransferase type 2 (MGAT2) inhibitors which may be used as medicaments.<；p>；SE DESCRIBEN COMPUESTOS DE LA FÓ；RMULA (I): O UN ESTEREOLSÓ；MERO O UNA SAL DE AQUEL ACEPTABLE DESDE EL PUNTO DE VISTA FARMACÉ；UTICO, EN DONDE TODAS LAS VARIABLES SON COMO SE DEFINEN EN LA PRESENTE. ESTOS COMPUESTOS SON INHIBIDORES DE MONOACILGLICEROL ACILTRANSFERASA TIPO 2 (MGAT2)； SUS COMPOSICIONES FARMACÉ；UTICAS Y SU USO EN EL TRATAMIENTO DE LA DIABETES, HIPERGLUCEMIA, RETINOPATÍ；A, SÍ；NDROME METABÓ；LICO, ENTRE OTROS.<；/p>；
