To prevent abuse of a pharmacologically active ingredient by an abuser by providing a pharmaceutical composition having an abuse-prevention function (abuse by nasal inhalation, abuse by injection, and abuse by extracting a drug and inhaling nasally or injecting). To provide: a pharmaceutical composition having an abuse-prevention function having both a physical barrier and a chemical barrier when an abuser tries to abuse the pharmaceutical composition; a method for producing same; and a method for using same.本發明之課題為藉由提供一種具有防止濫用功能之醫藥組成物,而防止濫用者對藥理活性成分之濫用(藉由從鼻吸入的濫用、藉由注射之濫用、藉由一度萃取藥物並從鼻吸入或注射之濫用)。提供一種具有在濫用者試圖濫用時兼具物理性阻隔或化學性阻隔之防止濫用功能的醫藥組成物、其製造方法、其使用方法。