A composition with an antibacterial effect on oral bacteria containing extracts of ginseng berries as an active ingredient is provided to ensure excellent antibacterial activity about the harmfulness oral microorganism, having low minimum inhibitory concentration while minimizing side effects. A composition with an antibacterial effect on oral bacteria comprises extracts of ginseng berries as an active ingredient. The ginseng fruit extract is crude saponin. The crude saponin is manufactured by adding ethanol to the dried material of ginseng berries, reflux-extracting, filtering and concentrating it； and after adding butanol after removing the fat-soluble component, extracting and concentrating it.본 발명의 인삼열매(Ginseng fruits) 추출물, 특히 에탄올을 가하여 추출 후 부탄올을 가하여 추출하여 제조된 조사포닌을 유효성분으로 함유하는 구강세균억제용 조성물은 충치균인 스트렙토코커스 뮤탄스(Streptococcus mutans) 또는 치주질환균인 플레보텔라 인터메디아(Prevotella intermedia)를 비롯한 유해 구강 미생물에 대한 항균활성이 우수하고, 천연물에서 추출되어 부작용이 최소화되어 식품, 의약, 화장품 산업상에 다양하게 응용할 수 있다.
