The invention relates to the use of Scleritine as an agent for protecting cells against toxic agents, including in particular chemical agents or physical agents. The invention relates to a dermatological and/or cosmetic composition for the skin which protects against toxic agents, characterized in that it comprises Scleritine in at least one excipient or carrier suitable for topical application. The field of the invention relates to the pharmaceutical industry or the cosmetics industry and more specifically for the formulation of pharmaceutical or cosmetic compositions intended for protecting cells against toxic agents.