Holger WESCHE,Bryan D. LEMON,Richard J. AUSTIN,Robert B. DUBRIDGE
申请号：
US15977988
公开号：
US20180327508A1
申请日:
2018.05.11
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided herein are mesothelin (MSLN) targeting trispecific proteins comprising a domain binding to CD3, a half-life extension domain, and a domain binding to MSLN. Also provided are pharmaceutical compositions thereof, as well as nucleic acids, recombinant expression vectors and host cells for making such MSLN targeting trispecific proteins. Also disclosed are methods of using the disclosed MSLN targeting trispecific proteins in the prevention, and/or treatment of diseases, conditions and disorders.
