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NOTCH SIGNAL WAY INHIBITORS AND THEIR APPLICATION FOR TREATMENT OF CANCER
专利权人:
ЭКОЛЬ ПОЛИТЕКНИК ФЕДЕРАЛЬ ДЕ ЛОЗАННА (ЭПФЛ) (CH)
发明人:
РАДТКЕ Фредди (CH),ЛЕХАЛ Райвиндер (CH),РЕЙНМЮЛЛЕР Виктория (CH),ЧЖУ Джипин (CH)
申请号:
RU2014127753
公开号:
RU2014127753A
申请日:
2012.12.21
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A compound for use in the treatment and / or prevention of Notch-dependent cancer, wherein said compound having inhibitory properties with respect to the Notch signaling pathway has the formula where m is an integer selected from 1-4; W is selected from Η and halogens; said halogen is selected from F-, Cl-, Br- or Ι-; R, R, R, R are each independently selected from the group consisting of H, isopropyl, tert-butyl, (CH) CH; the subscript n is an integer independently selected from 1-15; X is O, NR where R is H; Υ is N or CH; Ζ is NRR where R and R are H, or where m is an integer a number selected from 1-4; W is selected from Η and halogens; said halogen is selected from F-, Cl-, Br- or Ι-; R and R are each independently selected from the group consisting of H, tert-butyl, (CH) CH; the subscript n is an integer independently selected from 1-15; X is O, NR where R is H; Υ is N or CH; Ζ is NRR where R and R are H, or where m is an integer a number selected from 1-4; W is selected from Η and halogens; said halogen is selected from F-, Cl-, Br- or Ι-; R is independently selected from the group consisting of H, isopropyl, tert-butyl, (CH) CH; the subscript n is an integer independently selected from 1-15; X is O, NR, where R is H; Υ is N or CH; Ζ is NRNR, where R and R are H.2. A compound according to claim 1, selected from the group consisting of the following compounds: 6- (4-Tert-butylphenoxy) pyridin-3-amine (13) of the formula I4- (4-cyclohexylphenoxy) aniline of the formula IIIa6- (4 - ((3r , 5r, 7r) -adamantan-1-yl) phenoxy) pyridin-3-amine of the formula IVa6- (3- (tert-butyl) phenoxy) pyridin-3-amine of the formula IIe4- (4- (tert-butyl) phenoxy) -3-fluoroaniline of the formula IIf6- (4- (tert-pentyl) phenoxy) pyridin-3-amine of the formula IIg6- (4-butyl1. Соединение для применения в лечении и/или предотвращении зависимого от Notch рака, при этом указанное соединение, обладающее ингибирующими свойствами в отношении пути передачи сигнала Notch, имеет формулугде
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