A heart valve prosthesis includes a valve frame (2), on which frame several valve leaflets (8) are fastened, as well as a fastening region which connects axially onto the valve frame (2), for fastening in a blood vessel. The fastening region includes a stabilizing ring (14, 14′, 14″, 14″′,14″″) which defines a given shape and a given diameter and is connected to the valve frame (2) is a force-decoupled manner.
