PURPOSE: A method for preparing rosuvastatin hemicalcium salt using methyl 2-((4R,6S)-6-(triphenylphosphoranylidenemehtyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate is provided to obtain statin of high purity and high yield.CONSTITUTION: A method for preparing a compound of chemical formula 4 comprises: a step of reacting a compound of chemical formula 3 with 2,2-dimethoxypropane under the presence of acid and a step of adding alkaline to the reacted solution to prepare the compound of chemical formula 4. The acid includes methane sulfonic acid, paratoluene sulfonic acid, perchloric acid, hydrochloric acid, nitric acid, acetic acid, sulfuric acid, or trifluoreacetic acid. The alkaline includes sodium hydrogen carbonate, potassium hydrogen carbonate, potassium carbonate, triethylamine, and ammonium hydroxide.COPYRIGHT KIPO 2012본 발명은 스타틴(statin)의 신규한 중간체 메틸 2-((4R,6S)-6-(트리페닐포스포란일리덴메틸)-2,2-디메틸-1,3-디옥산-4-일)아세테이트{methyl 2-((4R,6S)-6-(triphenylphosphoranylidenemehtyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate}, 이의 제조방법 및 이를 이용한 로수바스타틴 헤미 칼슘염 제조방법을 제공한다.
