Niels Fisker Nielsen,Ellen Marie Straarup,Marie Wickstrom Lindholm
申请号：
US13140777
公开号：
US20120115936A1
申请日:
2010.06.14
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to oligomer compounds (oligomers), which target APO-B100 mRNA in a cell, leading to reduced expression of APO-B100. Reduction of APO-B100 expression is beneficial for the treatment of certain medical disorders, such as diseases associated with apolipoproteinB activity, such as in non-limiting example, different types of HDL/LDL cholesterol imbalance dyslipidemias, e.g., familial combined dyslipidemia (FCHL), acquired hyperlipidemia, hypercholesterolemia, statin-resistant hypercholesterolemia coronary artery disease (CAD), coronary heart disease (CHD), atherosclerosis.
