A sustained release oral pharmaceutical form suitable for single daily dose administration has a neutral microgranule coated with a mounting layer of active ingredient and pharmaceutically acceptable binder and a coating layer of a hydrophobic coating polymer of a non-water soluble cellulose derivative, and at least 20% of inert load in relation to dry weight of hydrophobic coating polymer. The pharmaceutical form has improved resistance to rapid release of active ingredient, particularly in the presence of alcohol.본 발명은 하루 1회 투여량을 가능하게 하고, 알코올에 기인한 활성 성분의 투여량의 즉각적인 방출에 대해 저항성인 신규한 경구 약학 조성물에 관한 것이다.