The application relates to an antibody or antigen-binding fragment thereof which binds to a CD38 protein with a KD value of 1 x 10-9 M or less. The antibody or antigen-binding fragment thereof has strong ability of specific recognition and binding to CD38； and CD38+ cells can be killed by antibody-dependent cell-mediated cytotoxicity ADCC, complement-dependent cytotoxic CDC and/or apoptosis. The application also provides a use of the antibody or antigen-binding fragment thereof for prevention and treatment of a tumor.本申請涉及一種抗體或其抗原結合片段，其以1×10-9M以下的KD值與CD38蛋白相結合。所述的抗體或其抗原結合片段對於CD38蛋白的特異性識別結合能力強、可藉由抗體依賴的細胞介導的細胞毒性ADCC、補體依賴的細胞毒性CDC和/或細胞凋亡殺死CD38+細胞。本申請還提供了所述抗體或其抗原結合片段在預防和治療腫瘤中的應用。
