THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE,VANDENBARK ARTHUR A,BURROWS GREGORY G,MEZA-ROMERO ROBERTO,BENEDEK GIL,ANDREW SHAYNE,MOONEY JEFFERY
申请号：
IN6140/DELNP/2014
公开号：
IN2014DN06140A
申请日:
2014.07.22
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
Disclosed herein are isolated major histocompatibility complex (MHC) class II al domain polypeptides and methods of use. In some embodiments the isolated polypeptide comprises or consists of an MHC class H al domain polypeptide (or portion thereof) and does not include an MHC class II a2 ß1 or ß2 domain. The disclosed MHC class H al domain polypeptides are of use in treating or inhibiting disorders in a subject such as inflammatory and/or autoimmune disorders. Also disclosed are methods of evaluating efficacy of treatment or optimizing treatment of a subject with a polypeptide including an MHC class II al domain polypeptide (or portion thereof) or a polypeptide including an MHC class II al domain and ß1 domain (such as a ß1a1 RTL).
