Problem to be solved: to provide a new therapeutic tool for autoimmune diseases and inflammatory diseases by newly identifying an endogenous nucleic acid having a strong immunogenicity that causes inflammation and suppressing immunogenicity of the nucleic acid.A nucleic acid molecule that suppresses the function of U11 snRNA, including sequences complementary to the partial sequence of consecutive 15 to 30 nucleotides in the nucleotide sequence of U11 snRNA.No selection【課題】炎症を惹起する強い免疫原性を有する内在性核酸を新規に同定し、該核酸の免疫原性を抑制することにより、自己免疫疾患や炎症性疾患の新規な治療手段を提供すること。【解決手段】U11 snRNAのヌクレオチド配列中、連続する15~30ヌクレオチドの部分配列と相補的な配列を含む、U11 snRNAの機能を抑制する核酸分子。【選択図】なし
