PATEL, A.k.,SHAH, Prakash J.,PATEL, K. R.,PATEL, M.r.
申请号：
PE0014452016
公开号：
PE11732016A1
申请日:
2015.02.10
申请国别(地区):
PE
年份:
2016
代理人:
摘要：
Refers to a topical formulation of pharmaceutically acceptable salts of heparin which comprises: (a) 50 to 2500 iu \/ ml of pharmaceutically acceptable salts of heparin (b) less than or equal to 30% V \/ V) Water, (c) 10% to 30% V \/ V of a Chain of Lower alcohol and (d) a vehicle misci Ble in water such as Propylene Glycol, glycerol, glycofurol,Polyethylene glycols or mixtures thereof. Furthermore, This formulation contains pharmaceutically acceptable excipients such as preservatives, stabilizers, antioxidants, among others. This formulation is characterized by an excellent transdermal penetration and improved Therapeutic Effectiveness when applied topically in conditions such as superficial Vein ThrombophlebitisSe refiere a una formulacion topica de sales farmaceuticamente aceptables de la heparina que comprende: a) 50 a 2500 UI/mL de sales farmaceuticamente aceptables de la heparina b) menos de o equivalente a 30 % v/v de agua, c) 10 % a 30 % v/v de una cadena de alcohol inferior y d) un vehiculo miscible en agua tal como propilenglicol, glicerol, glicofurol, polietilenglicoles u otras mezclas del mismo. Asimismo, dicha formulacion contiene excipientes farmaceuticamente aceptables tales como preservantes, antioxidantes, estabilizantes, entre otros. Dicha formulacion se caracteriza por una excelente penetracion transdermica y efectividad terapeutica mejorada cuando se aplica de manera topica en condiciones tal como tromboflebitis venosa superficial
