Thierry Guillaudeux;Charles L. Magness;Gary Rosenberg;SHAWN P. IADONATO;Christina A. Scherer
发明人:
SHAWN P. IADONATO,Charles L. Magness,Gary Rosenberg,Christina A. Scherer,Thierry Guillaudeux
申请号:
US13468937
公开号:
US20120321608A1
申请日:
2012.05.10
申请国别(地区):
US
年份:
2012
代理人:
摘要:
A method for detecting a mutation related to the gene encoding OAS1. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided is a therapeutic agent consisting of a protein or polypeptide encoded by the mutated gene, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human OAS1, including antisense oligonucleotides, methods, and compositions specific for human OAS1, are also provided.