СЕЛЛСЬЮТИКС КОРПОРЕЙШН;РУТГЕРС, ДЗЕ СТЕЙТ ЮНИВЕРСИТИ ОФ НЬЮ-ДЖЕРСИ;СЕЛЛСЬЮТИКС КОРПОРЕЙШН
发明人:
СКОТТ Ричард У.,ФРИМАН Кэти,ТАН Хайчжун,ДАЙМОНД Джилл
申请号：
RU2014133744
公开号：
RU2014133744A
申请日:
2013.01.18
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. A method of killing or inhibiting the growth of Candida or Aspergillus species or preventing or treating a mammal with oral or disseminated candidiasis or Aspergillus infection, comprising contacting the Candida or Aspergillus species with or administering to a mammal in need thereof an effective amount of a compound of formula I where each X is independently O, S or S (= O)； each R is independently -CH, - (CH) -NH, - (CH) -NH-C (= NH) NH or - (CH) -NH-C (= O) -R, where each n is independently 1-4 and each R is independently H, CC-alkyl or - (CH) -NH, where each p is independently 1 or and 2； each R denotes independently H, halogen, CF or C (CH)； each V denotes H and each V denotes independently -NC (= O) -R, where each R denotes independently - (CH) -NH or - (CH) -NH-C (= NH) NH, where each n is independently 1-4； or each V denotes H and each V denotes independently -S-R, where each R denotes independently - (CH) -NH or - (CH) -NH-C (= NH) NH, where each n is independently 1-4； each R is H, -S- (CH) -NH, -S- (CH) -NH-C (= NH) NH, -O- (CH) -NH or -O- (CH) -NH-C (= NH ) NH, where each m is independently 1-4； or a pharmaceutically acceptable salt thereof； or compounds of formula II where R is H； R is NH； each R is independently - (CH) -R, where R is selected from hydrogen, CC-alkyl, C-C-branched alkyl, CC-cycloalkyl, phenyl optionally substituted with one or more CC-alkyl groups, CC alkoxy groups or halogen groups, and heteroaryl optionally substituted with one or more CC alkyl groups, CC alkoxy groups or halogen groups； each R independently is hydroxyethoxymethyl, methoxyethoxymethyl, polyoxyethylene or - (CH) -V, where q has a value of 1 to 5 and each V is independently selected from amino, hydroxyl, CC-alkylamino, CC-dialkylamino, CC-alkylurea, -NH (CH) NH, -N (CHCHNH), amidine, guanidine, semicarbazone, imidazole, piperidine, piperazine, 4-alkylpiperazine, phenyl optionally substituted with amines1. Способ уничтожения или ингибирования роста видов Candida или A
