Georg Tschank;Gerhard Seipke;Mark Sommerfeld;Ulrich Werner;Paul Habermann;Norbert Tennagels;Roland Kurrle;Gunter Muller
发明人:
Paul Habermann,Gerhard Seipke,Roland Kurrle,Gunter Muller,Mark Sommerfeld,Norbert Tennagels,Georg Tschank,Ulrich Werner
申请号：
US12820727
公开号：
US08633156B2
申请日:
2010.06.22
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the addition and/or substitution of negatively and positively charged amino acid residues and by an amidation of the C-terminal carboxy group of the B chain and histidine in position 8 of the insulin A chain. The invention also relates to the production and use thereof.
