The present invention relates to compositions comprisingUbiquitous surface protein A2 (UspA2). More particularly, the present application relates to UspA2 protein constructs and immunogenic compositions comprising the constructs, vaccines comprising such immunogenic compositions and therapeutic uses of the same. The invention further relates to compositions comprising UspA2 in combination with at least one antigen fromimmunogenic compositions comprising the antigens, vaccines comprising such immunogenic compositions and therapeutic uses of the same.