Didier Philippe Robert Schils,Joannes Josephus Maria Willems,Bart Petrus Anna Maria Jozef Medaer,Elisabeth Therese Jeanne Pasquier,Paul Adriaan Jan Janssen,Jan Heeres,Ruben Gerardus George Leenders,Jé
申请号：
IS7621
公开号：
IS2980B
申请日:
2004.12.29
申请国别(地区):
IS
年份:
2017
代理人:
摘要：
Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]-amino]-2-pyrimidinyl]amino]benzonitrile of formula (I), a N-oxide, a pharmaceutically acceptable acid addition salt, a quaternary amine or a stereochemically isomeric form thereof are provided, said processes comprise: a) reacting 4-(2-cyanoethenyl)-2,6-dimethylbenzenamine with an intermediate of formula (III) in the presence of a suitable solvent； b) reacting an intermediate of formula (IV) with acrylonitrile in the presence of a suitable palladium catalyst, a suitable base and a suitable solvent； c) dehydrating the corresponding amide of the compound of formula (I).
