Topically administrable compositions and methods for treating skin conditions in mammals, such as acne, rosacea, keratosis pilaris, photo-aging, and photo-rejuvenation. The composition includes a therapeutic amount of antihistamine selected from the group consisting of a non-sedating antihistamine, a physiologically acceptable acid of a non-sedating antihistamine, a salt of a non-sedating antihistamine, an amide of a non-sedating antihistamine, and a combination of two or more of these, and emu oil product selected from the group consisting of emu oil, a biologically active fraction of emu oil, and a combination of these. The composition further includes a therapeutic amount of topical retinoid. The combination of non-sedating antihistamine and retinoid with emu oil has been found to produce a synergistic effect that is more effective in the treatment of skin conditions than the compound used separately.
