Eun-Joo Roh,Kye-Jung Shin,Changjoon Justin Lee,Soo Jin Oh,Jung-Eun Park,Jeong Eun Yang,Eun Mi Hwang,Dong Ho Woo,Soon-Hyouk Lee,Dong-Gyu Kim,Hee-jung Chun,Wan-Keun Ji,Yun-Soo Na
申请号：
US14361844
公开号：
US09458120B2
申请日:
2012.11.30
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to a novel phenoxypropanol derivative, represented by the structure of Chemical Formula I, and a racemate thereof, a pharmaceutically acceptable salt thereof, a solvate thereof and a hydrate thereof,wherein * represents an (R)-form or an (S)-form, X is selected from the group consisting of hydrogen, halogen and substituted or unsubstituted straight or branched alkyl having 1 to 4 carbon atoms, and n represents the number of X and an integer of 1 to 5, wherein at least a hydrogen is substituted with halogen in the substituted linear or branched alkyl having 1 to 4 carbon atoms. The derivative can be used for blocking T-type calcium channel and/or TREK channel, and for preventing and/or treating T-type calcium channel- and/or TREK channel-associated diseases.
