Ho Taek IM,Myoung Ki JEONG,Yong Il KIM,Jae Hyun PARK,Jong Soo WOO,Hyuk Jun CHO
申请号：
US15039238
公开号：
US20170027871A1
申请日:
2014.11.20
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Disclosed is a pharmaceutical combination formulation comprising a first discrete part containing amlodipine and rosuvastatin and a second discrete part containing losartan, which exhibits improved dissolution rate and stability. The inventive combination formulation comprising amlodipine, losartan and rosuvastatin having different action mechanisms from one another can be effectively used to prevent or treat a cardiovascular disorder. Designed to minimize an interaction among active ingredients, the pharmaceutical combination formulation exhibits excellent storage stability and dissolution rates of amlodipine, losartan and rosuvastatin, and thus can be useful in pharmaceutical industries.
