THE BRIGHAM AND WOMEN'S HOSPITAL, INC.;MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人:
JAY, STEVEN, M.,GRIFFITH, LINDA, G.,LEE, RICHARD, T.
申请号：
EP11760220
公开号：
EP2555788A4
申请日:
2011.03.24
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
The invention provides methods and compositions for reducing, preventing or reversing cardio toxicity side effects associated with certain therapeutic agents. The invention also provides methods and compositions for treating heart dysfunction including heart failure, and for reversing the effects of myocardial infarction. The various aspects of the invention involve the use of ligand dimers, such as neuregulin dimers, that selectively induce the dimerization of certain EGF receptors in cardiac tissue.
