SINGH, MANMOHAN,SKIBINSKI, DAVID A. G.,WU, TOM YAO-HSIANG,LI, YONGKAI,CORTEZ, ALEX,ZHANG, XIAOYUE,ZOU, YEFEN,HOFFMAN, TIMOTHY Z.,PAN, JIANFENG,YUE, KATHY
申请号：
CA2810011
公开号：
CA2810011A1
申请日:
2011.09.01
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
Immunopotentiators can be adsorbed to insoluble metal salts, such as aluminium salts, to modify their pharmacokinetics, pharmacodynamics, intramuscular retention time, and/or immunostimulatory effect. Immunopotentiators are modified to introduce a moiety, such as a phosphonate group, which can mediate adsorption. These modified compounds can retain or improve their in vivo immunological activity even when delivered in an adsorbed form.
