‘UFR-2’ is a new and distinct allotetraploid citrus rootstock for tree size control and improved disease resistance. ‘UFR-2’ has shown a positive reaction to the Huanglongbing disease (HLB, or citrus greening disease) in multiple experimental field trials. Scion trees grafted on this rootstock show a reduced frequency of infection and reduced disease symptoms once infected as compared to commercial diploid rootstocks.