CARY, STEPHEN P L,BOON, ELIZABETH M,WINGER, JONATHAN A,MARLETTA, MICHAEL A
申请号:
NZ59445607
公开号:
NZ594456A
申请日:
2007.05.21
申请国别(地区):
NZ
年份:
2013
代理人:
摘要:
NZ 594456 Disclosed is an isolated H-NOX protein comprising at least one distal pocket mutation wherein the mutation is a replacement of a residue that corresponds to position 74 of Thermoanaerobacter tengcongensis H-NOX by any other amino acid, wherein the mutation alters the NO dissociation constant or NO reactivity compared to that of a corresponding wild-type H-NOX protein.