Sherie L. Morrison,John M. Timmerman,Kham M. Trinh
申请号：
US14893912
公开号：
US20160115242A1
申请日:
2014.05.29
申请国别(地区):
US
年份:
2016
代理人:
摘要：
In various embodiments chimeric moieties (constructs) are provided that show significant efficacy against cancers. In certain embodiments the constructs comprise a targeting moiety that specifically binds CSPG4 attached to an interferon or to a mutant interferon. In certain embodiments, the constructs comprise anti-CSPG4 antibody attached to an interferon alpha (IFN-α) or to a mutant interferon alpha or to an interferon beta (IFN-β) or to a mutant interferon beta, or to an interferon gamma (IFN-γ) or to a mutant interferon gamma.
