SHON, Dong-Hwa,SHIN, Hee Soon,DO, Jeong-Ryong,LEE, So Young,CHOI, Dae Woon,JUNG, Sun Young,SEE, Hye-Jeong,KWON, Da-Ae,BACK, Su Yeon,EOM, Ji Eun
申请号：
WO2016KR13971
公开号：
WO2017099413(A1)
申请日:
2016.11.30
申请国别(地区):
世界知识产权组织国际局
年份:
2017
代理人:
摘要：
The present invention relates to a composition comprising an enzyme-treated Rosa multiflora fruit extract as an active ingredient for preventing or treating a Th2-mediated immune disease. The composition according to the present invention can maximize the anti-allergic effect of the Rosa multiflora fruit extract by comprising an enzyme-treated Rosa multiflora fruit extract as an active ingredient. Specifically, the present inventors verified that, as a result of treating splenocytes of OVA-immunized mice with an enzyme-treated Rosa multiflora fruit extract, the enzyme-treated Rosa multiflora fruit extract remarkably promoted IL-4 production inhibitory activity compared with an enzyme-non-treated Rosa multiflora fruit extract and the in vivo oral administration of the enzyme-treated Rosa multiflora fruit extract remarkably reduced the blood IgE content in the OVA-immunized mice. In addition, the composition according to the present invention has advantages of being biocompatible and having excellent stability
