Tony Taldone;Gabriela Chiosis;Mary L. Alpaugh;Jason S. Lewis;Erica M. Gomes;Nagavarakishore Pillarsetty;Steven M. Larson
发明人:
Gabriela Chiosis,Nagavarakishore Pillarsetty,Jason S. Lewis,Steven M. Larson,Tony Taldone,Mary L. Alpaugh,Erica M. Gomes
申请号：
US14131420
公开号：
US20140294725A1
申请日:
2012.07.06
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention concerns various methods of using labeled HSP90 inhibitors to improve treatment of cancer patients with HSP90 inhibitors, including ex vivo and in vivo methods for determining whether a tumor will likely respond to therapy with an HSP90 inhibitor. The disclosure provides a method for determining whether a tumor will likely respond to therapy with an HSP90 inhibitor which comprises the following steps: (a) contacting the tumor or a sample containing cells from the tumor with a detectably labeled HSP90 inhibitor which binds preferentially to a tumor-specific form of HSP90； (b) measuring the amount of labeled HSP90 inhibitor bound to the tumor or the tumor cells in the sample； and (c) comparing the amount of labeled HSP90 inhibitor bound to the tumor or the tumor cells in the sample measured in step (b) to the amount of labeled-HSP90 inhibitor bound to a reference.
