The present disclosure provides an acetabular defect reconstructive prosthesis, comprising: an iliac support, the iliac support including a support seat (11) and a connecting wing plate (12) provided on the support seat (11), and the support seat (11) being contacted and matched with an ilium (1); and an acetabular cup (20) rotatably connected with the support seat (11) together. The technical solutions of the present disclosure can effectively solve the problems of reconstruction and long-term stability of a peri-acetabular defect in the related technology.