The present disclosure relates to a device and a method for non-invasively applying optical radiation to photosensitive parts of the brain. In particular the present invention is directed to a device for non-invasive/trans-cranial light therapy comprising one or more radiation units adapted to direct optical radiation at one or more neuroanatomical brain structures of a user from at least one extra-cranial position below the cerebrum of the user, said device applied for use in altering and/or controlling the production, release, re-uptake and/or metabolism of dopamine or serotonin in at least one of said one or more neuroanatomical brain structures and/or in the body of the user.
