A first aspect of the invention relates to a device for a diagnosis and/or therapymonitoring of inflammatory diseases, such as rheumatoid arthritis. It comprisesat least a rest or support device (1) for holding at least one extremity (11) ofa person. Thereby, the support device has the task of facilitating the at leastone extremity, preferably two extremities, for instance the two hands to be comfortablyand immovably placed as long as possible. This support device can be providedwith a rest with several accessories, such as indentations, bowl-like recesses,ridges, elastic or non-elastic straps and/or loops, etc.. Furthermore, at leastan excitation source (2) for at least partially illuminating one extremity atleast with a radiation of defined excitation wavelength. Furthermore, at leastan image sensor (3) is incorporated for capturing at least a reference signalfrom the extremity as well as several signals from the regions of medical interest(ROI) of the extremity (11). Moreover, a device according to the invention comprisesa comparator for comparing the reference signal with the signals from the regionsof medical interest (ROI).
