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HIGH-THROUGHPUT IDENTIFICATION OF PATIENT-SPECIFIC NEOEPITOPES AS THERAPEUTIC TARGETS FOR CANCER IMMUNOTHERAPIES
专利权人:
NANTOMICS; LLC
发明人:
NGUYEN, Andrew,SANBORN, John,BENZ, Stephen,NIAZI, Kayvan,RABIZADEH, Shahrooz,SOON-SHIONG, Patrick,VASKE, Charles
申请号:
SG11201806282X
公开号:
SG11201806282XA
申请日:
2017.02.10
申请国别(地区):
SG
年份:
2018
代理人:
摘要:
200000 6 150000 100000 50000 0 Detection: DNA RNA netMHC A02:01 Restricted Samples Necepitopes EUCEC (14) ! THCA (10) 1STAD (1) _j READ (4) OPRAD (10) LUSC (15) LUAD (17) Ej KIRC (13) DHNSC (25) 3COAD (3) BRCA (28) BLCA (3) Cancer Gene Classification of Neoepitopes Non-Cancer Genes 1:1 Cancer Driving Genes 94% FIG. 2 W O 20 17 / 13969 4 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/139694 Al 17 August 2017 (17.08.2017) WIPO I PCT 111111111111110111011111111111010111110 0111011111011111111101111111111111110111111 (51) International Patent Classification: GOOF 19/18 (2011.01) A61K 39/00 (2006.01) C12Q 1/68 (2006.01) A61K 39/395 (2006.01) GO1N 33/569 (2006.01) A61K 47/50 (2017.01) GO1N 33/574 (2006.01) A61K 48/00 (2006.01) A61K 35/17 (2014.01) (21) International Application Number: PCT/US2017/017549 (22) International Filing Date: 10 February 2017 (10.02.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/294,665 12 February 2016 (12.02.2016) US (71) Applicants: NANTOMICS, LLC [US/US] 9920 Jeffer- son Boulevard, Culver City, CA 90232 (US). NANT HOLDINGS IP, LLC [US/US] 9920 Jefferson Boulevard, Culver City, CA 90232 (US). = (72) Inventors: NGUYEN, Andrew 9920 Jefferson Boulevard, Culver City, CA 90232 (US). SANBORN, John, Zachary 9920 Jefferson Boulevard, Culver City, CA 90232 (US). BENZ, Stephen, Charles 436 Park Way, Santa Cruz, CA 95062 (US). NIAZI, Kayvan 9920 Jeffer- son Boulevard, Culver City, CA 90232 (US). RABIZA- DEH, Shahrooz 9920 Jefferson Boulevard, Culver City, CA 90232 (US). SOON-SHIONG, Patrick 9920 Jeffer- son Boulevard, Culver City, CA 90232 (US). VASKE, Charles, Joseph 9920 Jefferson Boulevard, Culver City, CA 90232 (US). (74) Agents: FESSENMAIER, Martin et al. Fish & Tsang, LLP, 2603 Main Street, Suite 1000, Irvine, CA 9261
来源网站:
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