The present invention provides a novel liquid composition suitable forin-situformation of a depot system to deliver a bioactive substance in a controlled manner. The composition of the present invention comprises: (a) a hydrophobic non-polymeric carrier material (b)a water miscible biocompatible organic solvent that dissolves the hydrophobic no n-polymeric material (c) an ionic complex that is formed between an amphiphilic molecule and a bioactive substance having a net charge at neutral pH in water. The present invention also provides a method of manufacturing and use of the composition thereof.本發明提供一種適合於原位儲庫系統之新穎液體組合物,以一控制方式傳輸一生物活性物質。本發明組合物包括:一疏水性、非聚合物載體材料;一與水互溶之生物相容性有機溶劑,溶解該疏水性、非聚合物材料;一離子錯合物,由一兩性分子與一於水中中性酸鹼值具有一靜電荷之生物活性物質所形成。本發明亦提供一種該組合物之製造及使用方法。
