A universal surgical handle (10) includes a body (12) having a moveable handle (18, and elongate member (13) extending distally from the body (12), an actuation shaft (20), and a fire lock mechanism (60. The actuation shaft (20) defines first and second lock slots (24, 25) spaced axially apart. The moveable handle (18is operatively associated with the actuation shaft (20to effect longitudinal movement of the actuation shaft (20). The fire lock mechanism (60has a lock pawl (62) that is received within the first lock slot (24) during a first mode of operation of the handle (10to lock the actuation shaft (20) in first longitudinal position and is received within the second lock slot (25) during a second mode of operation of the handle (10) to lock the actuation shaft (20) in a second longitudinal position. The handle (10) is adapted to transition from a home position to the first or second mode of operation in response to a loading unit (110, 210) being coupled to the elongate member (13).